Valérie Dréville trained at the Théâtre national de Chaillot (with Antoine Vitez, Yannis Kokkos, Aurélien Recoing, Georges Aperghis) and at the Conservatoire national supérieur d'art dramatique de Paris (with Viviane Théophilides, Claude Régy, Gérard Desarthe, Daniel Mesguich).
Her theatre career was marked by her meeting Antoine Vitez, her teacher at Chaillot, who directed her in Électre, Le Soulier de satin, La Célestine, La Vie de Galilée (Comédie-Française). She joined the Comédie-Française in 1988, which she left in 1993. She has worked with many directors including Jean-Pierre Vincent, Alain Ollivier, Aurélien Recoing, Lluis Pasqual, Claudia Stavisky, Yannis Kokkos, Anastasia Vertinskaïa and Alexandre Kaliaguine, Alain Françon, Bruno Bayen, Luc Bondy. She plays under the direction of Claude Régy in Le Criminel by Leslie Kaplan, The Terrible Voice of Satan by Gregory Motton, Somebody is going to come by Jon Fosse, Knives in Hens by David Harrower, Death variations by Jon Fosse, Comme un chant de David, translation of the psalms by Henri Meschonnic, The death of Tintagiles by Maurice Maeterlinck.
She regularly travels to Russia to work alongside Anatoli Vassiliev and his troupe, with whom she plays Heiner Müller's Matériau-Médée, Thérèse philosophe and Anton Tchekhov's The Story of a Nobody. Valérie Dréville is associate artist of the Festival d'Avignon 2008.
Recently, she played in O'Neill's Long day’s journey into night, directed by Célie Pauthe; Et nous brûlerons unes à unes les villes endormies, text, images and staging by Sylvain Georges; Chic par accident, directed by Yves-Noël Genod ; Tristesse animal noir by Anja Hilling, directed by Stanislas Nordey; Ghosts by Henrik Ibsen, directed by Thomas Ostermeier; Perturbations from the novel by Thomas Bernhard, directed by Krystian Lupa; Schwanengesang D744 conceived and directed by Romeo Castelucci; Un Temps bis by Becket conceived by Georges Aperghis; La Bête dans la Jungle by Marguerite Duras directed by Célie Pauthe; The Seagull by Chekhov, directed by Thomas Ostermeier; Demons after Fedor Dostoesvski, directed by Sylvain Creuzevault and Freedom in Bremen by Rainer Werner Fassbinder, directed by Cédric Gourmelon.
On the silver screen, she notably shoots under the direction of Jean-Luc Godard, Philippe Garrel, Alain Resnais, Hugo Santiago, Arnaud Desplechin, Laetitia Masson, Michel Deville, Nicolas Klotz and recently Antoine Barraud, Pascale Breton and Jeanne Balibar.